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As a potential implementation of data storage using DNA molecules, multiple strands of DNA are stored unordered in a liquid container. When the data are needed, an array of DNA readers will sample the strands with replacement, producing a Poisson-distributed number of noisy reads for each strand. The primary challenge here is to design an algorithm that reconstructs data from these unsorted, repetitive, and noisy reads.

Synchronization errors, arising from both synthesis and sequencing noise, present a fundamental challenge in DNA-based data storage systems. These errors are often modeled as insertion-deletion-substitution (IDS) channels, for which maximum-likelihood decoding is quite computationally expensive. In this work, we propose a data-driven approach based on neural polar decoders (NPDs) to design decoders with reduced complexity for channels with synchronization errors.